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Present understanding of the cellular mechanism of action of bisphosphonates as in vitro and in vivo inhibitors of bone resorption is reviewed. This mechanism appears to involve the osteoclast at more than one stage of its maturation process, and way well be receptor-mediated, although the molecular mechanism itself is thus far unknown.


Journal article


Drugs exp clin res

Publication Date





109 - 114


Animals, Bone Resorption, Cells, Cultured, Cytokines, Diphosphonates, Humans, Osteoclasts