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Present understanding of the cellular mechanism of action of bisphosphonates as in vitro and in vivo inhibitors of bone resorption is reviewed. This mechanism appears to involve the osteoclast at more than one stage of its maturation process, and way well be receptor-mediated, although the molecular mechanism itself is thus far unknown.

Type

Journal article

Journal

Drugs exp clin res

Publication Date

1991

Volume

17

Pages

109 - 114

Keywords

Animals, Bone Resorption, Cells, Cultured, Cytokines, Diphosphonates, Humans, Osteoclasts