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Local production of prostaglandins by osteoblasts may be important in controlling the bone resorbing activity of some hormones which have receptors on osteoblasts. We have demonstrated that osteoblast-like cells derived from human bone can incorporate [14C]arachidonic acid into phospholipids and synthesise immunoreactive PGE. Parathyroid hormone increases both the release of incorporated arachidonic acid and the synthesis of PGE. This is the first demonstration of modulation of bone cell prostaglandin synthesis by a bone resorbing hormone.

Original publication

DOI

10.1016/0014-5793(84)80287-2

Type

Journal article

Journal

Febs lett

Publication Date

09/04/1984

Volume

169

Pages

49 - 52

Keywords

Arachidonic Acid, Arachidonic Acids, Bone Resorption, Bone and Bones, Calcitriol, Cells, Cultured, Humans, Osteoblasts, Parathyroid Hormone, Phospholipases A, Phospholipids, Prostaglandins E