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Following the discovery that the kidney is involved in the metabolism of vitamin D, a causal relationship has been sought between defective production of 1,25-dihydroxy vitamin D3 and bone disease in chronic renal failure. This paper reviews some of the clinical evidence for and against such a relationship, and considers the possible role of other vitamin D metabolites in the pathophysiology of renal bone disease.


Journal article


Proc eur dial transplant assoc

Publication Date





630 - 636


Bone Diseases, Kidney, Kidney Failure, Chronic, Liver, Osteomalacia, Phosphates, Vitamin D