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In the arthroplasty pseudomembrane surrounding a loose prosthesis there is a marked macrophage and foreign body giant cell (FBGC) response to implant-derived wear particles. These cells contribute to the osteolysis of loosening by releasing cytokines and growth factors which influence the formation and activity of osteoclasts. Using a panel of monoclonal antibodies directed against known cytokine/growth factor receptors, we have determined by immunohistochemistry whether arthroplasty macrophages, FB-GCs and osteoclasts express receptors for cytokines and growth factors that are known to modulate osteolysis. All these cell types reacted with antibodies directed against the following cytokine/growth factor receptors: gp130, IL-1R type 1, IL-2R, IL-4R, IL-6R, TNFR, M-CSFR, GM-CSFR and SCFR but not with antibodies directed against IL-3R and IL-8R. Arthroplasty macrophages, FBGCs and osteoclasts thus show a similar pattern of cytokine/growth factor receptor expression. This reflects the fact that arthroplasty macrophages are capable of osteoclast differentiation and that these cell types form part of the mononuclear phagocyte system. As regards the osteolysis of aseptic loosening, it also indicates that these cells are targets for numerous cytokines and growth factors which influence osteoclast formation and bone resorption.

Original publication

DOI

10.3109/17453679909000980

Type

Journal article

Journal

Acta orthopaedica Scandinavica

Publication Date

10/1999

Volume

70

Pages

452 - 458

Addresses

Nuffield Department of Orthopaedic Surgery, University of Oxford, UK.

Keywords

Hip Joint, Joint Capsule, Knee Joint, Macrophages, Giant Cells, Foreign-Body, Osteoclasts, Humans, Giant Cell Tumor of Bone, Bone Neoplasms, Osteolysis, Prosthesis Failure, Receptors, Cytokine, Receptors, Growth Factor, Reoperation, Immunohistochemistry, Equipment Failure Analysis, Immunophenotyping, Joint Prosthesis, Cell Differentiation, Adult, Aged, Middle Aged, Female