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The immunohistological features of rheumatoid nodules and rheumatoid synovium were examined using monoclonal and polyclonal antibodies raised against macrophages, HLA-DR, leucocyte common antigen, and immunoglobulin components. The palisading cells surrounding the necrotic centre of the rheumatoid nodule were shown to be HLA-DR positive leucocytes, mostly histiocytes. The inflammatory infiltrate associated with rheumatoid nodules showed many immunohistochemical similarities to that of rheumatoid synovium, including a preponderance of IgG positive plasma cells, and a similar number and microanatomical pattern of distribution of HLA-DR positive cells. The significance of these findings for the cellular immunopathology and aetiology of the rheumatoid lesion is discussed.

Original publication

DOI

10.1136/ard.47.5.398

Type

Journal article

Journal

Annals of the rheumatic diseases

Publication Date

05/1988

Volume

47

Pages

398 - 403

Addresses

Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital.

Keywords

Synovial Membrane, Leukocytes, Humans, Arthritis, Rheumatoid, Rheumatoid Nodule, Antigens, CD45, Antigens, Differentiation, Histocompatibility Antigens, HLA-DR Antigens, Immunoenzyme Techniques