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Osteoclasts (OCs) and other cells of the mononuclear phagocyte system possess receptors for adhesive proteins present in the extracellular matrix. The antigenic phenotype of OCs and foreign body giant cells (FBGCs) was investigated for the presence of several integrin molecules and other largely platelet-associated antigens involved in cell adhesion reactions. Both OCs and FBGCs expressed the alpha-chains of the vitronectin receptor (CD51) and of the VLA-2 (CDw49b) and VLA-4 (CDw49d) molecules as well as their respective beta-chains, gpIIIa (CD61) and CD29. OCs and FBGCs also expressed CD9 and CD55 (DAF-Decay Accelerating Factor) and strongly reacted with antibodies directed against fibrinogen, fibronectin and vitronectin; the latter are ligands for several of the above matrix protein receptors. The data suggest that cell-cell and cell-matrix interactions involving adhesive proteins may be important in OC and FBGC function.

Original publication

DOI

10.1007/bf00315989

Type

Journal article

Journal

Histochemistry

Publication Date

01/1991

Volume

96

Pages

169 - 176

Addresses

University of Oxford, Nuffield Department of Pathology, John Radcliffe Hospital, Headington, Oxford, UK.

Keywords

Hip Joint, Giant Cells, Foreign-Body, Osteoclasts, Humans, Glycoproteins, Fibrinogen, Vitronectin, Fibronectins, Receptors, Cell Surface, Integrins, Antigens, Human Platelet, Immunoenzyme Techniques