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To investigate the relationship between osteofibrous dysplasia (OFD) and adamantinoma, we analyzed the expression of several proto-oncogene products and extracellular matrix proteins by immunohistochemistry and correlated our results with histological and ultrastructural findings. C-fos and c-jun, but not c-Met, were observed in OFD and in the fibrous and epithelial components of differentiated and classical adamantinomas. Staining for collagen IV, laminin and galectin-3, a laminin binding protein was seen in OFD and around cell nests in adamantinoma. E-, P-, and N-cadherin expression was found in all cases of classical adamantinoma, but not in differentiated adamantinoma or OFD. Osteonectin was detected in both the epithelial and fibrous components of adamantinomas, but osteopontin and osteocalcin were not seen in classical adamantinomas. The results show common expression of a number of oncoproteins and bone matrix proteins in adamantinoma and OFD, some of which are associated with mesenchymal-to-epithelial cell transformation. These findings would be in keeping with the hypothesis that OFD represents a precursor lesion of adamantinoma. Differential expression of a number of bone matrix protein in adamantinoma may also be of diagnostic use in distinguishing these 2 lesions immunohistochemically.

Original publication

DOI

10.1016/j.humpath.2003.07.008

Type

Journal article

Journal

Human pathology

Publication Date

01/2004

Volume

35

Pages

69 - 74

Addresses

Department of Pathology, Oxford University, Oxford, UK.

Keywords

Humans, Ameloblastoma, Bone Neoplasms, Fibrous Dysplasia, Monostotic, Osteonectin, Proto-Oncogene Proteins c-fos, Proto-Oncogene Proteins c-jun, Neoplasm Proteins, Extracellular Matrix Proteins, Tumor Markers, Biological, Fluorescent Antibody Technique, Indirect, Immunoenzyme Techniques, Adolescent, Adult, Middle Aged, Child, Child, Preschool, Female, Male