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We report a case of ameloblastoma which uniquely showed heavy osteoclast-like giant cell accumulation and woven bone formation in the surrounding fibrous stroma. Immunohistochemistry showed that the giant cells were non-epithelial in origin and suggested that stromal factors (i.e., the presence or absence of mineralized bone) determines whether these cells express an osteoclastic antigenic phenotype.

Original publication

DOI

10.1111/j.1365-2559.1994.tb00015.x

Type

Journal article

Journal

Histopathology

Publication Date

11/1994

Volume

25

Pages

497 - 499

Addresses

International Nepal Fellowship, Pokhara.

Keywords

Giant Cells, Humans, Ameloblastoma, Maxillary Neoplasms, Adult, Female