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Knowledge of some of the fundamental biochemical factors that may influence the initiation and continued growth of bone-forming cell lines is presented. The discussion is limited to those factors shown experimentally to be present locally in bone tissue and synthesized in the environment of bone-forming cells. The current state of knowledge of basic research findings on osteogenic factors is given in detail. Cooperative actions of these locally produced and systemic factors are the primary stimuli that result in increased bone growth and volume.

Original publication

DOI

10.3109/17453678709146514

Type

Journal article

Journal

Acta orthopaedica Scandinavica

Publication Date

12/1987

Volume

58

Pages

673 - 684

Addresses

Nuffield Department of Orthopedics, University of Oxford, Nuffield Orthopedic Centre, England.

Keywords

Fibroblasts, Animals, Humans, Growth Substances, Cell Differentiation, Bone Development, Osteogenesis