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Soluble forms of ICAM-1, VCAM-1, E-selectin, L-selectin, P-selectin and, more recently, ICAM-3 are known to exist in human serum and have elevated levels in numerous diseases. Previous studies have demonstrated that in rheumatoid arthritis (RA) the levels of circulating sICAM-1 and sE-selectin are elevated relative to healthy controls. We have compared the serum profiles of these six soluble adhesion molecules in patients with RA (n = 22) to those seen in healthy controls (n = 10) using sandwich ELISA. In the patients, there were significant elevations of serum sICAM-1 (P < 0.0001), sICAM-3 (P = 0.0327), sVCAM-1 (P = 0.0025), sL-selectin (P = 0.0194) and sP-selectin (P = 0.0025), but not E-selectin (P = 0.0672). However, only sP-selectin was found to correlate with disease activity in the patients (r = 0.461, P < 0.05). Thus, there is a distinct profile of soluble adhesion molecules in RA of which only sP-selectin correlates with disease activity.

Original publication

DOI

10.1093/rheumatology/36.2.164

Type

Journal article

Journal

British journal of rheumatology

Publication Date

02/1997

Volume

36

Pages

164 - 169

Addresses

Cell Adhesion Laboratory, John Radcliffe Hospital, Headington, Oxford.

Keywords

Humans, Arthritis, Rheumatoid, L-Lactate Dehydrogenase, C-Reactive Protein, Cell Adhesion Molecules, Intercellular Adhesion Molecule-1, L-Selectin, E-Selectin, P-Selectin, Vascular Cell Adhesion Molecule-1, Biological Markers, Antigens, Differentiation, Antigens, CD, Enzyme-Linked Immunosorbent Assay, Reference Values, Adult, Aged, Middle Aged