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Most mammalian hydroxysteroid dehydrogenases known thus far belong to the protein superfamilies of short-chain dehydrogenases/reductases (SDR) and aldo-keto reductases (AKR). Whereas members of the AKR family are soluble, cytoplasmic enzymes, SDR-type hydroxysteroid dehydrogenases are also located to other subcellular compartments, i.e. endoplasmic reticulum, mitochondria or peroxisomes. Differential localization might play an important role in influencing the reaction direction of hydroxy dehydrogenase/oxo reductase pathways by determining the available nucleotide cofactor pool. Targeting signals for different subcellular organelles in human hydroxysteroid dehydrogenases have been identified, however, in several enzymes localization signals remain to be determined.

Type

Journal article

Journal

Molecular and cellular endocrinology

Publication Date

01/2001

Volume

171

Pages

99 - 101

Addresses

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77, Stockholm, Sweden.

Keywords

COS Cells, Cell Membrane, Peroxisomes, Endoplasmic Reticulum, Mitochondria, Subcellular Fractions, Animals, Humans, Isoenzymes, Hydroxysteroid Dehydrogenases, 11-beta-Hydroxysteroid Dehydrogenases, Peptide Fragments, Luminescent Proteins, Green Fluorescent Proteins, Recombinant Fusion Proteins, Microscopy, Fluorescence, Transfection, Sequence Alignment, Amino Acid Sequence, Molecular Sequence Data