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1. 1,25-Dihydroxycholecalciferol (1,25-(OH)2-D3) was given at a dose of 5-0 nmol (2-1 mug) daily by mouth for 4-12 days to three patients with hypophosphataemic (type I), vitamin D-resistant rickets. 2. 1,25-(OH)2-D3 increased intestinal absorption and urinary excretion of calcium without significant effect on the renal handling of phosphate or its plasma concentration. 3. It is concluded that in this type of vitamin D-resistant rickets the renal phosphate abnormality is unlikely to be due to diminished endogenous production of 1,25-(OH)2-D3. 4. The difference between this condition and other hypophosphataemic states is discussed.

Original publication

DOI

10.1042/cs0480177

Type

Journal article

Journal

Clinical science and molecular medicine

Publication Date

03/1975

Volume

48

Pages

177 - 186

Keywords

Bone and Bones, Kidney Tubules, Humans, Hypophosphatemia, Familial, Phosphates, Calcium, Hydroxycholecalciferols, Dihydroxycholecalciferols, Intestinal Absorption, Time Factors, Female