Temperature-controlled acoustofluidic production of microbubble contrast agents with enhanced stability and monodispersity
Iranmanesh I., Shrivastava S., Browning R., Carugo D., Stride E.
Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved. In this paper, we propose a simple acoustofluidic method for production of microbubble contrast agents in disposable microfluidic chips by the use of a low-frequency ultrasound transducer and a temperature controller unit. The technique is used to increase the lifetime and to narrow down the size distribution of the microbubbles as compared to traditional microfluidic-based methods.