Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The transforming growth factor beta (TGFβ) signalling pathway regulates a range of important cellular processes in a context-dependent manner. Recent discoveries have provided important insights into the regulation of the TGFβ pathway and its change from an antitumorigenic to a protumorigenic pathway. These findings may have important implications for cancer stem cell (CSC) functions and therapeutic strategies.

Original publication

DOI

10.1016/j.trecan.2020.03.010

Type

Journal article

Journal

Trends cancer

Publication Date

07/2020

Volume

6

Pages

538 - 540

Keywords

Smad2/3, TGFβ signalling pathway, cancer stem cells, epithelial-to-mesenchymal transition, gene expression, pancreatic tumorigenesis