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The transforming growth factor beta (TGFβ) signalling pathway regulates a range of important cellular processes in a context-dependent manner. Recent discoveries have provided important insights into the regulation of the TGFβ pathway and its change from an antitumorigenic to a protumorigenic pathway. These findings may have important implications for cancer stem cell (CSC) functions and therapeutic strategies.

Original publication

DOI

10.1016/j.trecan.2020.03.010

Type

Journal article

Journal

Trends cancer

Publication Date

07/2020

Volume

6

Pages

538 - 540

Keywords

Smad2/3, TGFβ signalling pathway, cancer stem cells, epithelial-to-mesenchymal transition, gene expression, pancreatic tumorigenesis