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BACKGROUND: Medication adherence refers to whether a patient takes medication according to the frequency prescribed, or continues to take a prescribed medication. Inadequate adherence to medication may cause alterations in risk-benefit ratios, resulting in reduced benefits, increased risks or both, and is significantly associated with adverse clinical outcomes and higher healthcare costs. We aim to examine the effect of a computer generated short message service (SMS) reminder in improving medication adherence, and inhibiting the aromatisation process amongst breast cancer women receiving oral aromatase inhibitor therapy. METHODS/DESIGN: In this randomised controlled trial, eligible patients will be equally allocated to receive either SMS reminder or standard care. The former receives weekly SMS reminder to take medication while the latter does not receive any. The primary endpoint of medication adherence at 1-year is assessed using the Simplified Medication Adherence Questionnaire, and compared using the χ2 test. Adjustment for baseline covariate and potential confounders will be made using the logistic regression. Secondary outcomes involving estrone and androstenedione levels will be compared using the analysis of covariance, whereas the estradiol levels (

Original publication




Journal article


Bmc cancer

Publication Date





Aromatase inhibitor therapy, Breast cancer, Medication adherence, Randomised controlled trial, SMS reminder, Adult, Aged, Aged, 80 and over, Aromatase Inhibitors, Breast Neoplasms, Female, Humans, Logistic Models, Medication Adherence, Middle Aged, Multicenter Studies as Topic, Prospective Studies, Randomized Controlled Trials as Topic, Text Messaging