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Epidemiological studies suggest that retarded growth in infancy is associated with low adult bone mass. The mechanism underlying this association is unknown, but the programming of GH secretion or sensitivity by environmental influences during early development may play a role. We examined this issue in a sample of 37 healthy men, aged 63-73 yr, whose weight gain in infancy had been recorded. Venous blood samples were obtained under standard conditions every 20 min over a 24-h period. Measurements were made of the GH secretory profile, insulin-like growth factor I (IGF-I), IGF-binding protein-1 and -3, and GH-binding protein. Bone mineral density was measured at the lumbar spine and femoral neck using dual energy x-ray absortiometry. There was a statistically significant association between peak GH concentration (r = 0.46; P < 0.01) and fasting IGF-I concentration (r = 0.46; P < 0.01) with femoral neck bone density. After allowing for the peak GH concentration, median GH was negatively (P < 0.05) associated with bone mineral density. Weight at 1 yr was not related to peak GH, but was strongly related to the median GH concentration (r = 0.42; P = 0.01). These observations are consistent with a dual effect of GH secretion on bone density. High peak GH values drive IGF-I production and maintain bone mineralization in adult life. However, integrated GH secretion, after adjusting for the effect of pulse amplitude, is negatively associated with bone density in adult life. This particular characteristic of the GH secretory profile correlates with growth during infancy and might be programmed by environmental factors during intrauterine or early postnatal life.

Original publication

DOI

10.1210/jc.83.1.135

Type

Journal article

Journal

The Journal of clinical endocrinology and metabolism

Publication Date

01/1998

Volume

83

Pages

135 - 139

Addresses

Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, United Kingdom.

Keywords

Femur, Spine, Humans, Body Weight, Birth Weight, Weight Gain, Human Growth Hormone, Insulin-Like Growth Factor I, Carrier Proteins, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 3, Biological Markers, Regression Analysis, Environment, Circadian Rhythm, Aging, Bone Density, Adult, Aged, Middle Aged, Male