IoT-Enabled Tissue-Engineering Bioreactors for Real-Time Remote Monitoring: A Trial Using a Thermal Module
Assyarify H., Nadhif MH., Gates W., Whulanza Y.
Current tissue engineering bioreactors do not allow for real-time remote monitoring of the engineered tissues. Meanwhile, the tissue culture in a bioreactor may occur for days and weeks, in which errors and breakdowns of the bioreactor are unfavorable. In this study, an internet-of-things (IoT) architecture was integrated into a bioreactor to enable real-time remote monitoring, featuring a PID-controlled thermal module. Six different PID control configurations were examined for maintaining the thermal perseverance in a bioreactor. The results of the measured temperature were parallelly delivered to a dedicated website using a Message Queuing Telemetry Transport protocol. All PID control configurations were able to maintain the temperature at 37°C, and the integration of the IoT system was successfully completed. The user was able to monitor the value of inside chamber temperature on the website in real-time.