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We report the synthesis of hydroxyl-radical (˙OH) responsive fluorescent probes that utilise the 3,5-dihydroxybenzyl (DHB) functionality. 4-Methylumbeliferone-DHB (Umb-DHB) and resorufin-DHB (Res-DHB) in the presence of ˙OH radicals resulted in significant increases in their respective fluorescent emission intensities at 460 nm and 585 nm. The incubation of Res-DHB in HeLa cells followed by therapeutic ultrasound (1 MHz) resulted in a significant increase in fluorescence emission intensity thus permitting the ability to monitor ultrasound-induced ˙OH production in live cells.

Original publication

DOI

10.1039/d3cc00364g

Type

Journal article

Journal

Chemical communications (cambridge, england)

Publication Date

03/2023

Addresses

Department of Engineering Science, Parks Road, Oxford, OX1 3PJ, UK. james.kwan@balliol.ox.ac.uk.