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Enhanced liver fibrosis (ELF) score is a noninvasive assessment for liver fibrosis. We aimed to evaluate the performance of changes in ELF score 3 years apart in combination with liver stiffness measurement (LSM)-hepatocellular carcinoma (HCC) score to predict HCC in chronic hepatitis B (CHB) patients. This is a prospective cohort study. Patients who underwent transient elastography (TE) examinations and at intermediate or high risk of HCC defined by LSM-HCC score were invited to repeat the examination about 3 years later. Their serum samples at these two time points were retrieved to assess the ELF score changes. The primary endpoint was HCC. There were 445 CHB patients (males: 73.9%; mean age: 51.6 ± 10.3 years) who received two TE examinations and ELF scores. Among them, 252 (56.6%) and 193 (43.4%) patients were at intermediate and high HCC risk at first assessment defined by LSM-HCC score, respectively. Kaplan-Meier analysis showed that the changes in ELF score could stratify the HCC risk in both intermediate- and high-risk patients defined by LSM-HCC score (p  20%). Consistent findings were demonstrated in patients at both intermediate and high risk of HCC defined by LSM-HCC score. Dynamic changes in ELF score provided additional value to LSM-HCC score for stratifying HCC risk in CHB patients.

Original publication

DOI

10.1111/jvh.14004

Type

Journal article

Journal

Journal of viral hepatitis

Publication Date

12/2024

Volume

31

Pages

808 - 819

Addresses

Medical Data Analytics Centre (MDAC), The Chinese University of Hong Kong, Hong Kong SAR, China.

Keywords

Humans, Hepatitis B, Chronic, Carcinoma, Hepatocellular, Liver Neoplasms, Liver Cirrhosis, Antiviral Agents, Prognosis, Severity of Illness Index, Prospective Studies, Adult, Middle Aged, Female, Male, Elasticity Imaging Techniques