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It is widely accepted that the likelihood of offspring developing heart disease, stroke, or diabetes in later life, is influenced by the their in utero environment and maternal nutrition. There is increasing epidemiological evidence that osteoporosis in the offspring may also be influenced by the mother's nutrition during pregnancy. This review provides evidence from a range of animal models that supports the epidemiological data; suggesting that lifelong bone development and growth in offspring is determined during gestation.

Type

Journal article

Journal

European cells & materials

Publication Date

01/2011

Volume

22

Pages

321 - 332

Addresses

Bone and Joint Research Group, Human Development and Health, Institute of Developmental Sciences, University of Southampton School of Medicine, Southampton, SO16 6YD, UK. sal3@ soton.ac.uk

Keywords

Bone and Bones, Animals, Humans, Osteoporosis, Fetal Nutrition Disorders, Disease Models, Animal, Diet, Nutritional Requirements, Fetal Development, Bone Development, Pregnancy, Female