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Invariant NKT (iNKT) cells modulate innate and adaptive immune responses through activation of myeloid dendritic cells and macrophages and via enhanced clonogenicity, differentiation, and egress of their shared myeloid progenitors. Because these same progenitors give rise to osteoclasts (OCs), which also mediate the egress of hematopoietic progenitors and orchestrate bone remodeling, we hypothesized that iNKT cells would extend their myeloid cell regulatory role to the development and function of OCs. In this study, we report that selective activation of iNKT cells by α-galactosylceramide causes myeloid cell egress, enhances OC progenitor and precursor development, modifies the intramedullary kinetics of mature OCs, and enhances their resorptive activity. OC progenitor activity is positively regulated by TNF-α and negatively regulated by IFN-γ, but is IL-4 and IL-17 independent. These data demonstrate a novel role of iNKT cells that couples osteoclastogenesis with myeloid cell egress in conditions of immune activation.

Original publication

DOI

10.4049/jimmunol.1002353

Type

Journal article

Journal

Journal of immunology (Baltimore, Md. : 1950)

Publication Date

03/2011

Volume

186

Pages

2910 - 2917

Addresses

Center for Hematology, Hammersmith Hospital, Imperial College London, London W12 0NN, United Kingdom.

Keywords

Dendritic Cells, Macrophages, Osteoclasts, Myeloid Cells, Stem Cells, Animals, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Mice, Tumor Necrosis Factor-alpha, Macrophage Colony-Stimulating Factor, Lymphocyte Activation, Cell Differentiation, Cell Movement, Down-Regulation, Up-Regulation, RANK Ligand, Interferon-gamma, Natural Killer T-Cells