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Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C(24) acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC(50) of 15.0 microg/mL.

Original publication

DOI

10.1021/np020572s

Type

Journal article

Journal

J Nat Prod

Publication Date

04/2003

Volume

66

Pages

569 - 571

Keywords

Acetylene, Alkynes, Animals, Fatty Acids, Unsaturated, Inhibitory Concentration 50, Japan, Matrix Metalloproteinases, Membrane-Associated, Metalloendopeptidases, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Oxidation-Reduction, Porifera, Protease Inhibitors, Stereoisomerism