Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C(24) acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC(50) of 15.0 microg/mL.

Type

Journal article

Journal

Journal of natural products

Publication Date

04/2003

Volume

66

Pages

569 - 571

Addresses

Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

Keywords

Animals, Porifera, Alkynes, Acetylene, Metalloendopeptidases, Fatty Acids, Unsaturated, Protease Inhibitors, Nuclear Magnetic Resonance, Biomolecular, Inhibitory Concentration 50, Molecular Structure, Oxidation-Reduction, Stereoisomerism, Japan, Matrix Metalloproteinases, Membrane-Associated