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Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C(24) acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC(50) of 15.0 microg/mL.


Journal article


Journal of natural products

Publication Date





569 - 571


Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.


Animals, Porifera, Alkynes, Acetylene, Metalloendopeptidases, Fatty Acids, Unsaturated, Protease Inhibitors, Nuclear Magnetic Resonance, Biomolecular, Inhibitory Concentration 50, Molecular Structure, Oxidation-Reduction, Stereoisomerism, Japan, Matrix Metalloproteinases, Membrane-Associated