Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Controlled cell migration is a fundamental and critical event in many physiological processes. However once control is lost, cell migration facilitates disease progression such as seen in cancer metastasis, atherosclerosis, and rheumatoid arthritis. One of the critical proteinases involved in cell migration is membrane-type 1 matrix metalloproteinase (MT1-MMP/MMP-14). MT1-MMP degrades extracellular matrix to make a path for cells to migrate, sheds cell surface molecules to give migratory signals, and activates ERK (extracellular signal-regulated protein kinase) enhancing cell migration. For MT1-MMP to promote cell migration, it needs to act in co-ordination with other cell migration machinery. Understanding such regulatory links may provide insights into the development of novel disease therapies.

Original publication

DOI

10.1080/15216540600962818

Type

Journal article

Journal

IUBMB life

Publication Date

10/2006

Volume

58

Pages

589 - 596

Addresses

Kennedy Institute of Rheumatology Division, Imperial College London, London, UK. y.itoh@imperial.ac.uk

Keywords

Extracellular Matrix, Animals, Cell Adhesion Molecules, Protein Precursors, Signal Transduction, Cell Movement, Matrix Metalloproteinase 2, Matrix Metalloproteinase 13, Matrix Metalloproteinase 14