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PRR (pattern-recognition receptor) signalling is involved early in the immune response and therefore would be attractive to target during vaccination. The use of PRR ligands has shown some success; however, toxicity and non-specificity are issues with this strategy. The targeting of PRR intracellular signalling networks would allow for greater specificity and reduced systemic toxicity. The present review examines the successes seen with overexpression or repression of PRR signalling molecules.

Original publication

DOI

10.1042/bst0351501

Type

Journal article

Journal

Biochemical Society transactions

Publication Date

12/2007

Volume

35

Pages

1501 - 1503

Addresses

Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, U.K.

Keywords

Immune System, Humans, Vaccines, DNA, Viral Vaccines, Adjuvants, Immunologic, Ligands, Vaccination, Signal Transduction, Receptors, Pattern Recognition