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There is now compelling evidence that immune responses for both foreign and self antigens are downregulated by T cells that are specialised for this function; these are known as regulatory T (T reg) cells. This review describes progress in the characterisation of the T reg cells that mediate both mucosal tolerance and tolerance to self antigens. The recent work on the antigen specificity, generation and mode of action of T reg cells is also reviewed.

Original publication

DOI

10.1016/s0952-7915(98)80084-8

Type

Journal article

Journal

Current opinion in immunology

Publication Date

12/1998

Volume

10

Pages

649 - 655

Addresses

MRC Cellular Immunology Unit Sir William Dunn School of Pathology University of Oxford Oxford OX1 3RE UK. Don.Mason@path.ox.ac.uk

Keywords

T-Lymphocytes, CD4-Positive T-Lymphocytes, Animals, Humans, Autoimmunity, Immunity, Mucosal