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It is now well established that regulatory T (T(R)) cells can inhibit harmful immunopathological responses directed against self or foreign antigens. However, many key aspects of T(R) cell biology remain unresolved, especially with regard to their antigen specificities and the cellular and molecular pathways involved in their development and mechanisms of action. We will review here recent findings in these areas, outline a model for how T(R) cells may inhibit the development of immune pathology and discuss potential therapeutic benefits that may arise from the manipulation of T(R) cell function.

Original publication




Journal article


Nature immunology

Publication Date





816 - 822


Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.


Thymus Gland, T-Lymphocyte Subsets, Animals, Humans, Mice, Autoimmune Diseases, Receptors, Interleukin-2, Antigens, Differentiation, Antigens, CD, Immunoconjugates, Cytokines, Cell Adhesion, Self Tolerance, Models, Immunological, T-Lymphocytes, Regulatory, CTLA-4 Antigen