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Alarmins are endogenous molecules that are constitutively available and released upon tissue damage and activate the immune system. Current evidence indicates that uncontrolled and excessive release of alarmins contributes to the dysregulated processes seen in many inflammatory and autoimmune conditions, as well as tumorigenesis and cancer spread. Conversely, alarmins have also been found to play a major role in the orchestration of tissue homeostasis, including repair and remodeling in the heart, skin, and nervous system. Here, we provide an update and overview on alarmins, highlighting the areas that may benefit from this clinical translation.

Type

Journal article

Journal

The Journal of clinical investigation

Publication Date

08/2012

Volume

122

Pages

2711 - 2719

Addresses

Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom. james.chan@kennedy.ox.ac.uk

Keywords

Animals, Humans, Sepsis, Neoplasms, Autoimmune Diseases, Inflammation, Inflammation Mediators, Biological Markers, Regenerative Medicine, Signal Transduction, Systemic Inflammatory Response Syndrome, Immunity, Innate, Adaptive Immunity