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Five patients with involutional osteoporosis were treated with 24,25 dihydroxycholecalciferol (24,25-(OH)2D3) for 6 months, in doses sufficient to double plasma levels at that time. Dietary calcium absorption transiently improved by nearly 2 mmol Ca per day at 2 weeks, but this effect was lost by 6 months. The calcium and phosphate balances followed the trends in calcium absorption. Only twenty-five dihydroxyvitamin D levels changed little. Histomorphometric and kinetic indices of new bone formation and bone blood flow remained stable but there was an increase in urine hydroxyproline at 6 months, which was of borderline statistical significance. Treatment at this dosage of 24,25(OH)2D3, which increased plasma levels within the physiological range, conferred no measurable long-term benefit on our patients. Larger doses, or combination therapy, may warrant further clinical evaluation in osteoporosis.

Original publication

DOI

10.1530/acta.0.1010636

Type

Journal article

Journal

Acta endocrinol (copenh)

Publication Date

12/1982

Volume

101

Pages

636 - 640

Keywords

24,25-Dihydroxyvitamin D 3, Calcium, Dihydroxycholecalciferols, Dose-Response Relationship, Drug, Humans, Osteoporosis, Time Factors