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The effects of the immunosuppressant Cyclosporin A (CsA) on T cell activation in vivo and in vitro were examined using the monoclonal antibody, anti-Tac, for interleukin 2 (IL-2) receptors and 3.9C2, for a peptide fragment of human IL-2. Peripheral blood lymphocytes (PBL) were stimulated with PHA in the presence of CsA. The expression of IL-2 receptors and production of IL-2 were reduced. PBL from CsA-treated MS patients had significantly lower proportions of Tac+ cells compared with untreated patients. This inhibition was not reflected in the CSF lymphocyte populations from CsA-treated patients and indicates the urgent need for an immunosuppressant drug which can enter the CNS in sufficient concentrations to inhibit local T cell activation.

Type

Journal article

Journal

Clinical and experimental immunology

Publication Date

12/1987

Volume

70

Pages

570 - 577

Addresses

Department of Neurochemistry, Institute of Neurology, London, UK.

Keywords

T-Lymphocytes, Humans, Multiple Sclerosis, Cyclosporins, Phytohemagglutinins, Receptors, Immunologic, Receptors, Interleukin-2, Interleukin-2, Fluorescent Antibody Technique, Lymphocyte Activation, Female, Male