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HLA Class II molecules are expressed by human thyroid epithelial cells (thyrocytes) in thyroid autoimmunity, although these cells are normally Class II-. gamma-Interferon (gamma-IFN) is probably involved in this expression, as suggested by its ability to induce Class II in cultured normal thyrocytes. We have now found that thyroid stimulating hormone (TSH) enhances Class II expression induced in cultured thyrocytes by gamma-IFN, and effects similar to those of TSH were obtained with dibutyryl cyclic AMP. A proportion of thyrocytes also expressed Class II following treatment with TSH or dibutyryl cyclic AMP in the absence of gamma-IFN, but the optimal activity of these mediators then appeared to be dependent upon the occurrence of some pre-existing Class II expression. These findings give insights into how a variety of mediators may influence Class II expression in thyroid autoimmunity.

Type

Journal article

Journal

Clinical and experimental immunology

Publication Date

09/1987

Volume

69

Pages

524 - 531

Addresses

Department of Immunology, Middlesex Hospital Medical School, London, UK.

Keywords

Thyroid Gland, Cells, Cultured, Humans, Autoimmune Diseases, Thyrotropin, Bucladesine, HLA-D Antigens, Drug Synergism, Interferon-gamma