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Cells in the immune and nervous systems communicate through informational synapses. The two-dimensional chemistry underlying the process of synapse formation is beginning to be explored using fluorescence imaging and mechanical techniques. Early analysis of two-dimensional kinetic rates (k(on) and k(off)) and equilibrium constants (K(d)) provides a number of biological insights. First, there are two regimes for adhesion-one disordered with slow k(on) and the other self-ordered with 10(4)-fold faster k(on). Despite huge variation in two-dimensional k(on), the two-dimensional k(off) is like k(off) in solution, and two-dimensional k(off) is more closely related to intrinsic properties of the interaction than the two-dimensional k(on). Thus difference in k(off) can be used to set signaling thresholds. Early signaling complexes are compartmentalized to generate synergistic signaling domains. Immune antigen receptor components have a role in neural synapse editing. This suggests significant parallels in informational synapse formation based on common two-dimensional chemistry and signaling strategies.

Original publication

DOI

10.1146/annurev.cellbio.17.1.133

Type

Journal article

Journal

Annual review of cell and developmental biology

Publication Date

01/2001

Volume

17

Pages

133 - 157

Addresses

Skirball Institute of Molecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA. dustin@saturn.med.nyu.edu

Keywords

Synapses, T-Lymphocytes, Humans, Antigens, CD4, Lymphocyte Activation, Cell Communication, Signal Transduction, Synaptic Transmission, Self Tolerance, Kinetics, Fluorescence