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'There is at bottom only one genuinely scientific treatment for all diseases, and that is to stimulate the phagocytes,' so declaimed Sir Ralph Bloomfield Bonington in The Doctor's Dilemma, Act 1, by George Bernard Shaw (1906). More often nowadays, the need is to calm the phagocytes, given their role in inflammation and tissue damage. In spite of the growth of cellular and molecular information gained from studies in macrophage cell culture, mouse models and, to a lesser extent, human investigations, and the importance of macrophages in pathogenesis in a wide range of chronic disease processes, there is still a substantial shortfall in terms of clinical applications. In this review, we summarize concepts derived from macrophage studies and suggest possible properties suitable for diagnosis, prognosis and selective targeting of macrophage pathogenic functions.

Original publication

DOI

10.1586/1744666x.2015.985658

Type

Journal article

Journal

Expert review of clinical immunology

Publication Date

01/2015

Volume

11

Pages

5 - 13

Addresses

Botnar Research Centre, University of Oxford, Windmill Road, Oxford, OX3 7LD, UK.

Keywords

Macrophages, Animals, Humans, Mice, Chronic Disease, Inflammation, Allergy and Immunology, History, 20th Century, History, 21st Century