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Tumour hypoxia represents a major challenge in the effective treatment of solid cancerous tumours using conventional approaches. As oxygen is a key substrate for Photo-/Sono-dynamic Therapy (PDT/SDT), hypoxia is also problematic for the treatment of solid tumours using these techniques. The ability to deliver oxygen to the vicinity of the tumour increases its local partial pressure improving the possibility of ROS generation in PDT/SDT. In this manuscript, we investigate the use of oxygen-loaded, lipid-stabilised microbubbles (MBs), decorated with a Rose Bengal sensitiser, for SDT-based treatment of a pancreatic cancer model (BxPc-3) in vitro and in vivo. We directly compare the effectiveness of the oxygen-loaded MBs with sulphur hexafluoride (SF6)-loaded MBs and reveal a significant improvement in therapeutic efficacy. The combination of oxygen-carrying, ultrasound-responsive MBs, with an ultrasound-responsive therapeutic sensitiser, offers the possibility of delivering and activating the MB-sensitiser conjugate at the tumour site in a non-invasive manner, providing enhanced sonodynamic activation at that site.

Original publication

DOI

10.1016/j.jconrel.2015.02.004

Type

Journal article

Journal

Journal of controlled release : official journal of the Controlled Release Society

Publication Date

04/2015

Volume

203

Pages

51 - 56

Addresses

Biomedical Sciences Research Institute, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK.

Keywords

Pancreas, Tumor Cells, Cultured, Animals, Mice, Inbred BALB C, Humans, Pancreatic Neoplasms, Oxygen, Rose Bengal, Photosensitizing Agents, Photochemotherapy, Drug Delivery Systems, Ultrasonic Therapy, Microbubbles, Male, Hypoxia