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Hip fractures are a common type of fragility fracture that afflict 293,000 Americans (over 5,000 per week) and 35,000 Canadians (over 670 per week) annually. Despite the large population impact the optimal fixation technique for low energy femoral neck fractures remains controversial. The primary objective of the FAITH study is to assess the impact of cancellous screw fixation versus sliding hip screws on rates of revision surgery at 24 months in individuals with femoral neck fractures. The secondary objective is to determine the impact on health-related quality of life, functional outcomes, health state utilities, fracture healing, mortality and fracture-related adverse events.FAITH is a multi-centre, multi-national randomized controlled trial utilizing minimization to determine patient allocation. Surgeons in North America, Europe, Australia, and Asia will recruit a total of at least 1,000 patients with low-energy femoral neck fractures. Using central randomization, patients will be allocated to receive surgical treatment with cancellous screws or a sliding hip screw. Patient outcomes will be assessed at one week (baseline), 10 weeks, 6, 12, 18, and 24 months post initial fixation. We will independently adjudicate revision surgery and complications within 24 months of the initial fixation. Outcome analysis will be performed using a Cox proportional hazards model and likelihood ratio test.This study represents major international efforts to definitively resolve the treatment of low-energy femoral neck fractures. This trial will not only change current Orthopaedic practice, but will also set a benchmark for the conduct of future Orthopaedic trials.The FAITH trial is registered at ClinicalTrials.gov (Identifier NCT00761813).

Original publication

DOI

10.1186/1471-2474-15-219

Type

Journal article

Journal

BMC musculoskeletal disorders

Publication Date

26/06/2014

Volume

15

Keywords

FAITH Investigators, Humans, Femoral Neck Fractures, Postoperative Complications, Treatment Outcome, Clinical Protocols, Fracture Fixation, Internal, Reoperation, Likelihood Functions, Proportional Hazards Models, Prosthesis Design, Bone Screws, Research Design, Time Factors, Quality of Life, North America, Asia, Australia, Europe