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The short-chain dehydrogenase/reductase (SDR) superfamily represents one of the largest protein superfamilies known to date. Enzymes of this family usually catalyse NAD(P)(H) dependent reactions with a substrate spectrum ranging from polyols, retinoids, steroids and fatty acid derivatives to xenobiotics. We have currently identified 73 SDR superfamily members within the human genome. A status report of the human SDR superfamily is provided in terms of 3D structure determination, co-factor preferences, subcellular localisation and functional annotation. A simple scoring system for measuring structural and functional information (SFS score) has also been introduced to monitor the status of 5 key metrics. Currently there are 17 SDR members with an SFS score of zero indicating that almost a quarter of the human SDR superfamily lacks substantial functional annotation.

Original publication

DOI

10.1016/j.cbi.2008.10.058

Type

Journal article

Journal

Chemico-biological interactions

Publication Date

03/2009

Volume

178

Pages

99 - 109

Addresses

Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, UK.

Keywords

Oxidoreductases Acting on CH-CH Group Donors, Computational Biology, Protein Conformation, Structure-Activity Relationship, Models, Molecular