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After the identification of the interleukin (IL)-1 type II receptor as the prototype, decoy receptors have been identified for a number of members of the IL-1/IL-18, TNF, IL-10 and IL-13 receptor families. Moreover, the silent receptor D6 is a promiscuous decoy and scavenger receptor of inflammatory chemokines. The IL-1 decoy receptor is regulated by pro- and anti-inflammatory signals and its levels may serve as a readout of the activation of anti-inflammatory pathways, for instance by glucocorticoid hormones. Decoy receptors represent a strategy to tune inflammatory and polarized adaptive responses.

Original publication

DOI

10.1159/000073711

Type

Journal article

Journal

International archives of allergy and immunology

Publication Date

10/2003

Volume

132

Pages

109 - 115

Addresses

Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Faculty of Medicine, University of Milan, Milan, Italy. Mantovani@marionegri.it

Keywords

Receptors, Chemokine, Receptors, Interleukin-1, Interleukin-1, Cytokines, Receptors, Interleukin-1 Type II, Immunity, Innate