Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Both rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have an increased familial occurrence and each disease is associated with the inheritance of specific HLA antigens. We report a pair of identical twin brothers with discordant disease phenotypes: one developed AS at the age of 26, and the other developed RA at the age of 55. The twins possessed both of the disease susceptibility antigens HLA B27 and DR4. Differences in the twins' environmental exposure are discussed.

Type

Journal article

Journal

Clinical and experimental rheumatology

Publication Date

07/1993

Volume

11

Pages

425 - 428

Addresses

ARC Epidemiology Research Unit, Manchester, U.K.

Keywords

Humans, Spondylitis, Ankylosing, Arthritis, Rheumatoid, Diseases in Twins, HLA-B27 Antigen, HLA-DR4 Antigen, Radiography, Twins, Monozygotic, Middle Aged, Male