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5 sets of criteria for diagnosis of Behçet's disease are in use--a problem which has hindered interpretation of different studies and collaborative research. An international study group, which included at least one proponent of 4 of the sets, was formed to derive new, internationally agreed diagnostic criteria for Behçet's disease. Data on 914 patients with Behçet's disease, from 12 centres in 7 countries, were compared with controls from the same centres. The new set of diagnostic criteria--which requires the presence of oral ulceration plus any two of genital ulceration, typical defined eye lesions, typical defined skin lesions, or a positive pathergy test--was simpler to use and had an improved discriminatory performance than its predecessors.


Journal article


Lancet (London, England)

Publication Date





1078 - 1080


Humans, Behcet Syndrome, Stomatitis, Aphthous, Eye Diseases, Genital Diseases, Male, Genital Diseases, Female, Skin Ulcer, Recurrence, Ulcer, Skin Tests, Sampling Studies, Predictive Value of Tests, Algorithms, Reference Standards, Female, Male, Multicenter Studies as Topic