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To perform an external validation of FRAX algorithm thresholds for reporting level of risk of fracture in Spanish women (low < 5%; intermediate ≥ 5% and < 7.5%; high ≥ 7.5%) taken from a prospective cohort "FRIDEX".A retrospective study of 1090 women aged ≥ 40 and ≤ 90 years old obtained from the general population (FROCAT cohort). FRAX was calculated with data registered in 2002. All fractures were validated in 2012. Sensitivity analysis was performed.When analyzing the cohort (884) excluding current or past anti osteoporotic medication (AOM), using our nominated thresholds, among the 621 (70.2%) women at low risk of fracture, 5.2% [CI95%: 3.4-7.6] sustained a fragility fracture; among the 99 at intermediate risk, 12.1% [6.4-20.2]; and among the 164 defined as high risk, 15.9% [10.6-24.2]. Sensitivity analysis against model risk stratification FRIDEX of FRAX Spain shows no significant difference. By including 206 women with AOM, the sensitivity analysis shows no difference in the group of intermediate and high risk and minimal differences in the low risk group.Our findings support and validate the use of FRIDEX thresholds of FRAX when discussing the risk of fracture and the initiation of therapy with patients.

Original publication

DOI

10.1016/j.maturitas.2015.10.002

Type

Journal article

Journal

Maturitas

Publication Date

01/2016

Volume

83

Pages

65 - 71

Addresses

Department of Medicine, Universitat Autònoma de Barcelona, ps/Vall d' Hebron 119, 08135 Barcelona, Spain; Health Center Badia del Valles (ICS), GROIMAP-USR MN-IDIAP Jordi Gol, c/Bética s/n, 08214 Badia del Vallés Barcelona, Spain; Idc-Hospital General de Catalunya, Universitat Internacional de Catalunya, c/Josep Trueta s/n, 08195 Sant Cugat del Vallès, Barcelona, Spain. Electronic address: rafael.azagra@uab.cat.

Keywords

GROIMAP and FROCAT Study Group, Humans, Risk Assessment, Risk Factors, Retrospective Studies, Algorithms, Aged, Middle Aged, Spain, Female, Osteoporotic Fractures