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Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity, and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the generation of these epigenetic changes in vivo will contribute to the clinical exploitation of Foxp3(+) Treg. Here, we show that both in vitro and in vivo generated antigen-specific Foxp3(+) Treg can acquire Treg-specific epigenetic characteristics and prevent skin graft rejection in an animal model.

Original publication

DOI

10.3389/fimmu.2016.00124

Type

Journal article

Journal

Frontiers in immunology

Publication Date

01/2016

Volume

7

Addresses

Therapeutic Immunology Group, Sir William Dunn School of Pathology, University of Oxford , Oxford , UK.