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Targeted delivery of potent, toxic chemotherapy drugs, such as cisplatin, is a significant area of research in cancer treatment. In this study, cisplatin was successfully encapsulated with high efficiency (>70%) in poly (lactic-co-glycolic acid) polymeric nanoparticles by using electrohydrodynamic atomization (EHDA) where applied voltage and solution flow rate as well as the concentration of cisplatin and polymer were varied to control the size of the particles. Thus, nanoparticles were produced with three different drug:polymer ratios (2.5, 5 and 10wt% cisplatin). It was shown that smaller nanoparticles were produced with 10wt% cisplatin. Furthermore, these demonstrated the best sustained release (smallest burst release). By fitting the experimental data with various kinetic models it was concluded that the release is dependent upon the particle morphology and the drug concentration. Thus, these particles have significant potential for cisplatin delivery with controlled dosage and release period that are crucial chemotherapy parameters.

Original publication

DOI

10.1016/j.nano.2016.05.005

Type

Journal article

Journal

Nanomedicine : nanotechnology, biology, and medicine

Publication Date

10/2016

Volume

12

Pages

1919 - 1929

Addresses

Mechanical Engineering, University College London, London, United Kingdom.

Keywords

Humans, Cisplatin, Glycols, Lactic Acid, Polyglycolic Acid, Antineoplastic Agents, Drug Delivery Systems, Particle Size, Nanoparticles