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Inflammatory bowel disease (IBD) is characterized by dysregulated immune responses to the intestinal microbiota, and by chronic intestinal inflammation. Several recent studies demonstrate the importance of innate microbial recognition by immune and nonimmune cells in the gut. Paradoxically, either diminished or exacerbated innate immune signaling may trigger the breakdown of intestinal homeostasis, leading to IBD and colitis-associated cancer (CAC). This dichotomy may reflect divergent functional roles for immune sensing in intestinal epithelial cells and leukocytes, which may vary with distinct disease mechanisms.

Type

Journal

The Journal of experimental medicine

Publication Date

08/2010

Volume

207

Pages

1573 - 1577

Addresses

Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, England, UK. mark.asquith@path.ox.ac.uk

Keywords

Intestines, Animals, Humans, Intestinal Neoplasms, Colitis, Inflammatory Bowel Diseases, Homeostasis, Immunity, Innate