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Diagnosis of implant-related (periprosthetic joint) infections poses a major challenge to infection disease physicians and orthopaedic surgeons. Conventional diagnostic tests continue to suffer from issues of accuracy and feasibility. Biomarkers are used throughout medicine for diagnostic and prognostic purposes, as they are able to objectively determine the presence of a disease or a biological state. There is increasing evidence to support the measurement of specific biomarkers in serum and/or synovial fluid of patients with suspected periprosthetic joint infections. Promising serum biomarkers include interleukin (IL)-4, IL-6, tumour necrosis factor (TNF)-α, procalcitonin, soluble intercellular adhesion molecule 1 (sICAM-1), and D-dimer. In addition to c-reactive protein and leucocyte esterase, promising biomarkers that can be measured in synovial fluid include antimicrobial proteins such as human β-defensin (HBD)-2 and human β-defensin (HBD)-3, and cathelicidin LL-37, as well as several interleukins such as IL-1β, IL-6, IL-8, IL-17, TNF- α, interferon-δ, and vascular endothelial growth factor.

Original publication

DOI

10.1007/5584_2017_11

Type

Journal article

Journal

Advances in experimental medicine and biology

Publication Date

01/2017

Volume

971

Pages

69 - 79

Addresses

The Rothman Institute, 925 Chestnut Street, Philadelphia, PA, 19107, USA. abtin.alvand@ndorms.ox.ac.uk.

Keywords

Humans, Prosthesis-Related Infections, Wounds and Injuries, Tumor Necrosis Factor-alpha, C-Reactive Protein, Interleukins, Orthopedics, Biomarkers