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Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by the destruction of joint tissues including cartilage and bone. Cartilage degradation is attributed to metalloproteinases (MPs) that belong to matrix metalloproteinase family and a disintegrin and metalloprotease with thrombospondin type 1 motifs produced by inflamed joint tissues. In addition, an enzyme that belongs to a disintegrin and metalloprotease family is also involved in release of inflammatory cytokines. Several highly selective inhibitors have been developed for MPs thought to play a role in RA pathogenesis and examining these inhibitors as potential drugs is becoming realistic. This chapter discusses recent reports on MPs in RA and their potential as a therapeutic target.

Original publication

DOI

10.1016/bs.pmbts.2017.03.002

Type

Chapter

Publication Date

01/2017

Volume

148

Pages

327 - 338

Addresses

Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom. Electronic address: yoshi.itoh@kennedy.ox.ac.uk.