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Levels of soluble adhesion molecules have been shown to reflect their cell surface expression in vitro, and thus may provide a useful surrogate marker of surface expression at inflammatory sites. In patients with SLE and vasculitis, serum levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-Selection were determined by ELISA during different stages of disease activity. Levels of soluble(s) VCAM-1 correlated with disease activity in patients with SLE, being significantly higher during active compared with inactive disease (P = 0.003), and normalizing with clinical remission. By contrast, in patients with vasculitis, although sVCAM-1 levels were elevated in active disease, they fell but did not normalize in inactive disease, suggesting that treatment may be suppressing the clinical manifestations rather than targeting the underlying pathogenic mechanism. Soluble ICAM-1 and E-Selectin levels did not relfect disease activity in either SLE or vasculitis.

Original publication

DOI

10.1093/rheumatology/33.12.1112

Type

Journal article

Journal

British journal of rheumatology

Publication Date

12/1994

Volume

33

Pages

1112 - 1116

Addresses

Department of Rheumatology, University of Birmingham.

Keywords

Humans, Vasculitis, Lupus Erythematosus, Systemic, Cell Adhesion Molecules, Intercellular Adhesion Molecule-1, E-Selectin, Vascular Cell Adhesion Molecule-1, Biological Markers, Enzyme-Linked Immunosorbent Assay, Severity of Illness Index, Cross-Sectional Studies, Adolescent, Adult, Aged, Middle Aged, Female, Male