Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Publications

Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation.

Fu S. et al, (2019), Osteoarthritis cartilage

Mechanoadaptation: articular cartilage through thick and thin.

Vincent TL. and Wann AKT., (2019), J physiol, 597, 1271 - 1281

Prominin-1 controls stem cell activation by orchestrating ciliary dynamics.

Singer D. et al, (2019), Embo j, 38

Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1-mediated endocytosis.

Coveney CR. et al, (2018), Faseb j

Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.

Thompson CL. et al, (2017), Eur cell mater, 34, 128 - 141

IFT88 influences chondrocyte actin organization and biomechanics.

Wang Z. et al, (2016), Osteoarthritis cartilage, 24, 544 - 554

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β.

Thompson CL. et al, (2015), Arthritis res ther, 17

The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity.

Wann AKT. et al, (2014), Cell signal, 26, 1735 - 1742

Are cellular mechanosensors potential therapeutic targets in osteoarthritis?

Drexler S. et al, (2014), International journal of clinical rheumatology, 9, 155 - 167

Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells.

McMurray RJ. et al, (2013), Sci rep, 3

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium.

Wann AK. et al, (2013), Cilia, 2

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response.

Wann AKT. and Knight MM., (2012), Cell mol life sci, 69, 2967 - 2977

Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes.

Wann AKT. et al, (2012), Faseb j, 26, 1663 - 1671

The role of the primary cilium in chondrocyte response to mechanical loading.

Wann AKT. et al, (2012), Mechanically gated channels and their regulation, mechanosensitivity in cells no.6

Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation.

Wann AKT. et al, (2010), Arthritis res ther, 12

Signal pathways regulating hyaluronan secretion into static and cycled synovial joints of rabbits.

Ingram KR. et al, (2009), J physiol, 587, 4361 - 4376

Mechanosensitive hyaluronan secretion: stimulus-response curves and role of transcription-translation-translocation in rabbit joints.

Wann AKT. et al, (2009), Exp physiol, 94, 350 - 361

Past, Present and Future Insights into the Understanding and Treatment of Osteoarthritis: Molecular and Mechanical Approaches

(2009), International journal of experimental pathology, 90, A30 - A84

Cyclic movement stimulates hyaluronan secretion into the synovial cavity of rabbit joints.

Ingram KR. et al, (2008), J physiol, 586, 1715 - 1729

Include forthcoming?