Use of oxygen-loaded nanobubbles to improve tissue oxygenation: Bone-relevant mechanisms of action and effects on osteoclast differentiation.
Journal article
Knowles HJ. et al, (2024), Biomaterials, 305
Editorial: Advances in the endocrine role of the skeleton volume II.
Journal article
Rossi M. et al, (2023), Front endocrinol (lausanne), 14
Mature primary human osteocytes in mini organotypic cultures secrete FGF23 and PTH1-34-regulated sclerostin.
Journal article
Knowles HJ. et al, (2023), Front endocrinol (lausanne), 14
A New Method to Sort Differentiating Osteoclasts into Defined Homogeneous Subgroups.
Journal article
Hulley PA. and Knowles HJ., (2022), Cells, 11
Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.
Conference paper
Cottone L. et al, (2022), Cell death differ
Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs.
Journal article
Larrouture QC. et al, (2021), Sci rep, 11
Hypoxia-inducible factor (HIF)-mediated effects of the hypoxic niche in bone cancer
Chapter
Knowles HJ., (2021), Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, 321 - 335
Distinct roles for the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in human osteoclast formation and function
Journal article
Knowles H., (2020), Scientific reports
Osteoblast-Osteoclast Coculture Amplifies Inhibitory Effects of FG-4592 on Human Osteoclastogenesis and Reduces Bone Resorption.
Journal article
Hulley PA. et al, (2020), Jbmr plus, 4
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.
Journal article
Gooding S. et al, (2019), Nat commun, 10
The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments.
Journal article
Knowles HJ., (2019), Cells, 8
Osteoclasts are multinucleated cells that degrade cartilage as well as bone
Conference paper
Larrouture QC. et al, (2018), Jbmr plus, 2, 17 - 18
Specific analysis of osteoclast-mediated bone resorption by differentiation of primary human osteoclasts in 3D
Conference paper
KNOWLES H. and Papadimitriou-Olivgeri I., (2018)
BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.
Journal article
Ngeow KC. et al, (2018), Proc natl acad sci u s a, 115, E8668 - E8677
Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis.
Journal article
Zhang T. et al, (2018), Bmc cancer, 18
The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia
Conference paper
Knowles HJ., (2018)
'Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2'.
Journal article
(2017), J pathol, 242
Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2.
Journal article
Hulley PA. et al, (2017), J pathol, 242, 322 - 333
Hypoxia-Induced Fibroblast Growth Factor 11 Stimulates Osteoclast-Mediated Resorption of Bone.
Journal article
Knowles HJ., (2017), Calcif tissue int, 100, 382 - 391
Multiple Roles of Angiopoietin-Like 4 in Osteolytic Disease.
Journal article
Knowles HJ., (2017), Front endocrinol (lausanne), 8