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Publications

Use of oxygen-loaded nanobubbles to improve tissue oxygenation: Bone-relevant mechanisms of action and effects on osteoclast differentiation.

Knowles HJ. et al, (2023), Biomaterials, 305

Mature primary human osteocytes in mini organotypic cultures secrete FGF23 and PTH1-34-regulated sclerostin.

Knowles HJ. et al, (2023), Front endocrinol (lausanne), 14

A New Method to Sort Differentiating Osteoclasts into Defined Homogeneous Subgroups.

Hulley PA. and Knowles HJ., (2022), Cells, 11

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.

Cottone L. et al, (2022), Cell death differ

Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs.

Larrouture QC. et al, (2021), Sci rep, 11

Hypoxia-inducible factor (HIF)-mediated effects of the hypoxic niche in bone cancer

Knowles HJ., (2021), Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, 321 - 335

Distinct roles for the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in human osteoclast formation and function

Knowles H., (2020), Scientific reports

Osteoblast-Osteoclast Coculture Amplifies Inhibitory Effects of FG-4592 on Human Osteoclastogenesis and Reduces Bone Resorption.

Hulley PA. et al, (2020), Jbmr plus, 4

Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.

Gooding S. et al, (2019), Nat commun, 10

The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments.

Knowles HJ., (2019), Cells, 8

Osteoclasts are multinucleated cells that degrade cartilage as well as bone

Larrouture QC. et al, (2018), Jbmr plus, 2, 17 - 18

Specific analysis of osteoclast-mediated bone resorption by differentiation of primary human osteoclasts in 3D

KNOWLES H. and Papadimitriou-Olivgeri I., (2018)

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.

Ngeow KC. et al, (2018), Proc natl acad sci u s a, 115, E8668 - E8677

Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis.

Zhang T. et al, (2018), Bmc cancer, 18

The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia

Knowles HJ., (2018)

'Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2'.

(2017), J pathol, 242

Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2.

Hulley PA. et al, (2017), J pathol, 242, 322 - 333

Hypoxia-Induced Fibroblast Growth Factor 11 Stimulates Osteoclast-Mediated Resorption of Bone.

Knowles HJ., (2017), Calcif tissue int, 100, 382 - 391

Multiple Roles of Angiopoietin-Like 4 in Osteolytic Disease.

Knowles HJ., (2017), Front endocrinol (lausanne), 8

How does hypoxia-inducible factor (HIF) regulate osteoclastogenesis and bone erosion?

Knowles HJ. et al, (2016), Frontiers in endocrinology: bone research

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