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Publications

Distinct roles for the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in human osteoclast formation and function

Knowles H., (2020), Scientific reports

Osteoblast-osteoclast co-culture amplifies inhibitory effects of FG-4592 on human osteoclastogenesis and reduces bone resorption

Knowles HJ. et al, (2020), Jbmr plus

Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.

Gooding S. et al, (2019), Nat commun, 10

The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments.

Knowles HJ., (2019), Cells, 8

Osteoclasts are multinucleated cells that degrade cartilage, as well as bone

KNOWLES H. et al, (2018)

Specific analysis of osteoclast-mediated bone resorption by differentiation of primary human osteoclasts in 3D

KNOWLES H. and Papadimitriou-Olivgeri I., (2018)

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.

Ngeow KC. et al, (2018), Proc natl acad sci u s a, 115, E8668 - E8677

Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis.

Zhang T. et al, (2018), Bmc cancer, 18

The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia

Knowles HJ., (2018)

'Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2' (vol 242, pg 322, 2017)

Hulley PA. et al, (2017), Journal of pathology, 242, 513 - 513

Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2.

Hulley PA. et al, (2017), J pathol, 242, 322 - 333

Hypoxia-Induced Fibroblast Growth Factor 11 Stimulates Osteoclast-Mediated Resorption of Bone.

Knowles HJ., (2017), Calcif tissue int, 100, 382 - 391

Multiple Roles of Angiopoietin-Like 4 in Osteolytic Disease.

Knowles HJ., (2017), Front endocrinol (lausanne), 8

How does hypoxia-inducible factor (HIF) regulate osteoclastogenesis and bone erosion?

Knowles HJ. et al, (2016), Frontiers in endocrinology: bone research

Hypoxia, hypoxia-inducible factor (HIF) and bone homeostasis: focus on osteoclast-mediated bone resorption

Knowles HJ., (2015), Trends in cell & molecular biology

Hypoxic regulation of osteoclast differentiation and bone resorption activity.

Knowles HJ., (2015), Hypoxia (auckl), 3, 73 - 82

Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure.

Hulley PA. et al, (2014), Cell death dis.

Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure.

Poulsen RC. et al, (2014), Cell death dis, 5

Angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption.

Swales C. et al, (2014), Plos one, 9

Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts.

Morten KJ. et al, (2013), J pathol, 229, 755 - 764

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