Mature primary human osteocytes in mini organotypic cultures secrete FGF23 and PTH1-34-regulated sclerostin.
Journal article
Knowles HJ. et al, (2023), Front endocrinol (lausanne), 14
A New Method to Sort Differentiating Osteoclasts into Defined Homogeneous Subgroups.
Journal article
Hulley PA. and Knowles HJ., (2022), Cells, 11
Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.
Conference paper
Cottone L. et al, (2022), Cell death differ
Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs.
Journal article
Larrouture QC. et al, (2021), Sci rep, 11
Hypoxia-inducible factor (HIF)-mediated effects of the hypoxic niche in bone cancer
Chapter
Knowles HJ., (2021), Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, 321 - 335
Distinct roles for the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in human osteoclast formation and function
Journal article
Knowles H., (2020), Scientific reports
Osteoblast-Osteoclast Coculture Amplifies Inhibitory Effects of FG-4592 on Human Osteoclastogenesis and Reduces Bone Resorption.
Journal article
Hulley PA. et al, (2020), Jbmr plus, 4
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.
Journal article
Gooding S. et al, (2019), Nat commun, 10
The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments.
Journal article
Knowles HJ., (2019), Cells, 8
Osteoclasts are multinucleated cells that degrade cartilage, as well as bone
Conference paper
KNOWLES H. et al, (2018)
Specific analysis of osteoclast-mediated bone resorption by differentiation of primary human osteoclasts in 3D
Conference paper
KNOWLES H. and Papadimitriou-Olivgeri I., (2018)
BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.
Journal article
Ngeow KC. et al, (2018), Proc natl acad sci u s a, 115, E8668 - E8677
Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis.
Journal article
Zhang T. et al, (2018), Bmc cancer, 18
The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia
Conference paper
Knowles HJ., (2018)
'Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2'.
Journal article
(2017), J pathol, 242
Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2.
Journal article
Hulley PA. et al, (2017), J pathol, 242, 322 - 333
Hypoxia-Induced Fibroblast Growth Factor 11 Stimulates Osteoclast-Mediated Resorption of Bone.
Journal article
Knowles HJ., (2017), Calcif tissue int, 100, 382 - 391
Multiple Roles of Angiopoietin-Like 4 in Osteolytic Disease.
Journal article
Knowles HJ., (2017), Front endocrinol (lausanne), 8
How does hypoxia-inducible factor (HIF) regulate osteoclastogenesis and bone erosion?
Conference paper
Knowles HJ. et al, (2016), Frontiers in endocrinology: bone research
Hypoxia, hypoxia-inducible factor (HIF) and bone homeostasis: focus on osteoclast-mediated bone resorption
Journal article
Knowles HJ., (2015), Trends in cell & molecular biology