Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.
Yamamoto K. et al, (2017), Arthritis rheumatol, 69, 1246 - 1256
Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.
Santamaria S. et al, (2017), Mabs, 9, 595 - 602
MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.
Yamamoto K. et al, (2016), Matrix biol, 56, 57 - 73
Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.
Doherty CM. et al, (2016), J biol chem, 291, 22160 - 22172
The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer.
Watanabe K. et al, (2016), J biol chem, 291, 20891 - 20899
Distinct biological events generated by ECM proteolysis by two homologous collagenases.
Solomonov I. et al, (2016), Proc natl acad sci u s a, 113, 10884 - 10889
Abrogation of prostaglandin E-EP4 signaling in osteoblasts prevents the bone destruction induced by human prostate cancer metastases.
Watanabe K. et al, (2016), Biochem biophys res commun, 478, 154 - 161
BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice.
Watanabe K. et al, (2016), Biochem biophys res commun, 478, 279 - 285
Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro.
Imada K. et al, (2016), Biochem biophys res commun, 476, 352 - 358
Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.
Ismail HM. et al, (2016), Arthritis rheumatol, 68, 1165 - 1171
Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity.
Poulet B. et al, (2016), Plos one, 11
Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2).
Santamaria S. et al, (2015), Biochem j, 471, 391 - 401
Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes.
Ismail HM. et al, (2015), Arthritis rheumatol, 67, 1826 - 1836
YAP is essential for tissue tension to ensure vertebrate 3D body shape.
Porazinski S. et al, (2015), Nature, 521, 217 - 221
Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.
Gardiner MD. et al, (2015), Osteoarthritis cartilage, 23, 616 - 628
DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis.
Hu H-Y. et al, (2015), Bioconjug chem, 26, 383 - 388
Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.
Lund J. et al, (2015), J biol chem, 290, 6620 - 6629
Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15.
Kelwick R. et al, (2015), Int j cancer, 136, E14 - E26