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Publications

Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.

Yamamoto K. et al, (2017), Arthritis rheumatol, 69, 1246 - 1256

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.

Santamaria S. et al, (2017), Mabs, 9, 595 - 602

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.

Scilabra SD. et al, (2017), Matrix biol, 59, 69 - 79

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.

Yamamoto K. et al, (2016), Matrix biol, 56, 57 - 73

Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.

Doherty CM. et al, (2016), J biol chem, 291, 22160 - 22172

The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer.

Watanabe K. et al, (2016), J biol chem, 291, 20891 - 20899

Distinct biological events generated by ECM proteolysis by two homologous collagenases.

Solomonov I. et al, (2016), Proc natl acad sci u s a, 113, 10884 - 10889

Abrogation of prostaglandin E-EP4 signaling in osteoblasts prevents the bone destruction induced by human prostate cancer metastases.

Watanabe K. et al, (2016), Biochem biophys res commun, 478, 154 - 161

BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice.

Watanabe K. et al, (2016), Biochem biophys res commun, 478, 279 - 285

A personal journey with matrix metalloproteinases.

Nagase H., (2016), Biol chem, 397, 805 - 813

Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro.

Imada K. et al, (2016), Biochem biophys res commun, 476, 352 - 358

Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.

Ismail HM. et al, (2016), Arthritis rheumatol, 68, 1165 - 1171

Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity.

Poulet B. et al, (2016), Plos one, 11

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2).

Santamaria S. et al, (2015), Biochem j, 471, 391 - 401

Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes.

Ismail HM. et al, (2015), Arthritis rheumatol, 67, 1826 - 1836

YAP is essential for tissue tension to ensure vertebrate 3D body shape.

Porazinski S. et al, (2015), Nature, 521, 217 - 221

Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.

Gardiner MD. et al, (2015), Osteoarthritis cartilage, 23, 616 - 628

DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis.

Hu H-Y. et al, (2015), Bioconjug chem, 26, 383 - 388

Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.

Lund J. et al, (2015), J biol chem, 290, 6620 - 6629

Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15.

Kelwick R. et al, (2015), Int j cancer, 136, E14 - E26

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