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Publications

Transplantation Without Overimmunosuppression (TWO) study protocol: a phase 2b randomised controlled single-centre trial of regulatory T cell therapy to facilitate immunosuppression reduction in living donor kidney transplant recipients.

Brook MO. et al, (2022), Bmj open, 12

“Virtual ward” community outreach support for COVID ‐19‐positive hemodialysis patients may delay but not prevent subsequent admission to hospital: A single‐center retrospective case–control pilot study

Gaied J. et al, (2021), Hemodialysis international

Towards regulatory cellular therapies in solid organ transplantation.

Bottomley MJ. et al, (2021), Trends immunol

Feasibility, Long-term Safety and Immune Monitoring of Regulatory T Cell Therapy in Living Donor Kidney Transplant Recipients.

Harden PN. et al, (2020), Am j transplant

New frontiers: cellular immunotherapy beyond cancer

Brook M. et al, (2019), Cell and gene therapy insights, 5, 1229 - 1236

Design for Health

Tsekleves E. and Cooper R., (2017)

Repeat testing is essential when estimating chronic kidney disease prevalence and associated cardiovascular risk.

Brook MO. et al, (2012), Qjm, 105, 247 - 255

Single estimated glomerular filtration rate and albuminuria measurement substantially overestimates prevalence of chronic kidney disease.

Bottomley MJ. et al, (2011), Nephron clin pract, 117, c348 - c352

Regulatory T cells can prevent memory CD8+ T-cell-mediated rejection following polymorphonuclear cell depletion.

Jones ND. et al, (2010), Eur j immunol, 40, 3107 - 3116

Location and time-dependent control of rejection by regulatory T cells culminates in a failure to generate memory T cells.

Carvalho-Gaspar M. et al, (2008), J immunol, 180, 6640 - 6648

Allograft rejection mediated by memory T cells is resistant to regulation.

Yang J. et al, (2007), Proc natl acad sci u s a, 104, 19954 - 19959

The impact of memory T cells on rejection and the induction of tolerance.

Brook MO. et al, (2006), Transplantation, 82, 1 - 9

Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help.

Jones ND. et al, (2006), J immunol, 176, 2316 - 2323

Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade.

Brook MO. et al, (2005), Transplantation, 80, 253 - 254

Include forthcoming?