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Hulley Group | Integrated musculoskeletal tissue modelling

  • Botnar
  • Tissue remodelling and regeneration

Hulley group research is directed towards understanding skeletal tissue disease pathology and devising effective regenerative strategies.

Human mini-bone
Osteocytes and osteoblasts in self-assembling organotypic mini-bone

The group combines human tissue omics with organotypic culture approaches. 3D multi-lineage organotypic bones and tendons are generated from patient-derived human primary cells or iPSC with CRISPR mutations. These are used for drug discovery and rare bone disease modelling. Multiphasic tissues are currently in development. Ongoing comparison is made to data derived from single cell atlases of bone and  tendon, as well as large scale synovial fluid proteomics studies.

Our team

Recent publications

Fibroblast specialisation across microanatomy in a single-cell atlas of healthy human Achilles tendon

Preprint

Cohen CJ. et al, (2025)

Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution.

Journal article

Mimpen JY. et al, (2025), J Physiol, 603, 4535 - 4554

Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution

Preprint

Mimpen J. et al, (2024)

Single nucleus and spatial transcriptomic profiling of healthy human hamstring tendon.

Journal article

Mimpen JY. et al, (2024), FASEB J, 38

SYNOVIAL FLUID BASED MOLECULAR ENDOTYPES IN KNEE OSTEOARTHRITIS: FULL PRIMARY ANALYSIS FROM THE STEPUp OA CONSORTIUM

Conference paper

Deng Y. et al, (2024), Osteoarthritis and Cartilage, 32, S55 - S56

IDENTIFYING MOLECULAR PATHWAYS ASSOCIATED WITH RADIOGRAPHIC STAGE IN KNEE OSTEOARTHRITIS THROUGH LARGE-SCALE PROTEOMICS OF SYNOVIAL FLUID: DATA FROM THE STEPUP OA CONSORTIUM

Journal article

Perry TA. et al, (2024), Osteoarthritis and Cartilage, 32, S473 - S473

Use of oxygen-loaded nanobubbles to improve tissue oxygenation: Bone-relevant mechanisms of action and effects on osteoclast differentiation.

Journal article

Knowles HJ. et al, (2024), Biomaterials, 305

Development of methodology to support molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: The STEpUP OA consortium.

Journal article

Deng Y. et al, (2024), PLoS One, 19

A roadmap for delivering a human musculoskeletal cell atlas.

Journal article

Baldwin M. et al, (2023), Nat Rev Rheumatol, 19, 738 - 752

Mature primary human osteocytes in mini organotypic cultures secrete FGF23 and PTH1-34-regulated sclerostin.

Journal article

Knowles HJ. et al, (2023), Front Endocrinol (Lausanne), 14

Related research themes

Tissue remodelling and repair
Tissue remodelling and repair
Translational medicine
Translational medicine